A new generation of immunotherapy (CAR-T) has been a great success in the treatment of cancer, which has been able to accurately target cancer cells by transforming the acquired immune system. However, people seem to have forgotten another branch of the immune system - innate immunity. In fact, the innate immune system is not idle during the course of cancer, and contrary to the acquired immune system, they are contributing to the development of cancer. Recently, scientists at the Dana-Farber Cancer Institute published a report in Nature that they discovered a compound that can "reverse" congenital immune cells.
This compound can turn congenital immune cells from the power of cancer to the enemy. In a mouse model, this compound is capable of atrophy of breast tumors and successfully prevents the metastasis of cancer cells. When used in combination with chemotherapy or other immunotherapies, this compound significantly prolongs tumor remission.
“These findings provide us with a new way of thinking about fighting cancer, which is to mobilize all available immune system resources. Most cancer immunotherapy today is through the transformation of T cells (an acquired immune cell) to make them accurate. Ground attack on cancer cells," said Dr. Jennifer Guerriero, the lead author of the article. "This strategy has been effective against several types of cancer, but only a few patients benefit from it. We want to make use of both innateness and acquiredness." The immune system achieves better therapeutic results."
Good or bad macrophages
The study was conducted on a congenital immune cell called tumor-associated macrophage (TAM). Although they are part of the immune system, they often appear inside the tumor and promote tumor growth. In fact, macrophages are good or bad depending on the signals that their surroundings provide to them.
For example, during wound healing, macrophages are able to modulate the various components of the immune system, remove damaged tissue cells in time, and further participate in repairing damaged tissue regions. Tumor-associated macrophages use their repairing ability to help tumor growth. It seems to treat cancer as a wound that cannot be healed. Therefore, cancer cells must have signaled some tissue damage, taking macrophages for their own use.
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