New research data show that the lack of prohormone convertase is associated with hormone abnormalities in Prader-Willi syndrome.
Prader-Willi syndrome is caused by hypothalamic dysfunction, and its symptoms include an appetite and severe obesity in childhood.
"Although we have known for a long time that genes are associated with Prader-Willi syndrome, we have been unclear how genetic mutations induce these diseases," Lisa C., Columbia University Pediatrics Center. Dr. Burnett. “Now we have discovered the key link between these mutations and the major hormonal features of the syndrome, and we can begin to look for new, more precise targeted therapies.â€
The researchers used stem cell technology to conceal skin cells from Prader Willi syndrome patients and control groups into brain cells. Cell analysis showed that the level of prohormone convertase (PC1) in patients with Prader Willi syndrome was significantly lower than that in the control group compared with the control group.
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