Release date: 2016-03-30
In recent years, scientists have spent a lot of effort in revealing the development of cancer, pathogenesis, new therapies and preventive measures. With the deepening of research and the discovery of various mechanisms, scientists have turned cancer into a kind of Controlled diseases.
Some of the cancer treatments we are familiar with, such as chemotherapy, radiotherapy, etc., and the cancer immunotherapy that has emerged in recent years is a therapy against the human immune system rather than direct tumors. This treatment treats the human immune system rather than directly Tumor.
Recently, scientists from the Texas A&M Health Science Center found that extracts from broccoli called sulforaphane may help treat cancer; others have found that meditation can also help cancer treatment; such positive research There are many, and some researchers have found that other components of the body may affect the occurrence of cancer. For example, in a research report published in Science, scientists from France found that intestinal microbes can affect the effectiveness of cancer immunotherapy.
In this article, Xiaobian has taken a variety of new ideas and new methods for treating cancer, and I will study with you.
[1] Nano artificial red blood cells can accurately treat cancer
Recently, Dr. Zheng Mingbin from the School of Pharmacy of Guangdong Medical University and Cai Lintao and Ma Yifan from the Institute of Advanced Technology of the Chinese Academy of Sciences made breakthroughs in the visualization of cancer by nano artificial red blood cells. The related results were published in the famous international academic journal Scientific Reports.
According to Zheng Mingbin, the team used a polymer-loaded photosensitizer (phthalocyanine green)-oxygen carrier (hemoglobin) complex to cover the phospholipid layer similar to the red blood cell membrane, and constructed nano artificial red blood cells with oxygen and oxygen release functions. . Nano-artificial red blood cells carry hemoglobin, oxygen and photosensitizers into the tumor, breaking through the obstacles of photodynamic therapy caused by tumor hypoxia microenvironment and insufficient oxygen supply; laser irradiation produces singlet oxygen and high-valent iron that kill cells. Hemoglobin achieves efficient treatment of tumors.
[2] Science Supplement: "Adaptation Therapy" - Using Evolutionary Thoughts to Treat Cancer
Conventional cancer chemotherapy means that the human body endures the limit of the drug dose in order to kill the cancer cells as much as possible. However, a recent study has developed a more modest approach to cancer treatment that yields better therapeutic outcomes than conventional chemotherapy.
The new treatment developed by American scientists is called "adaptive therapy," which does not kill as many cancer cells as possible, but uses low-dose drugs to maintain a subset of cancer-sensitive cancers. The survival of the cells, so that the cell group tolerated by the chemical is in a suppressed state.
"We have always chosen to use high doses of chemical stimulation because we agree that the higher the dose, the more cells are killed," said cancerist Robert Gatenby of the Moffitt Cancer Center in Florida.
[3] broccoli extract or can treat cancer
A compound found in broccoli sprouts not only helps prevent cancer, but also hopes to cure cancer. This compound is called Sulforaphane and is widely found in vegetables such as kale, broccoli, cabbage, especially in high-concentration broccoli shoots. Sulforaphane can also be used as a dietary supplement for the treatment of degenerative neurological diseases (BSE). Scientists at the Texas A&M Health Center Research Institute and researchers in Oregon, USA, have previously found that sulforaphane inhibits colon and prostate cancer cells in laboratory in vitro cell tests. They have now shown that this compound has a similar effect in humans.
In a clinical study, 28 volunteers over the age of 50 were undergoing routine colonoscopy. The researchers also conducted a survey of the eating habits of their cruciferous vegetables. Their colon biopsy found that the expression of the tumor suppressor gene p16 gene was higher in volunteers who frequently ate broccoli, whereas those with little or no cruciferous vegetables had low levels of expression.
[4] SCB: plant or food drug or treat cancer
According to new research, many plants and foods can be found to help people treat incurable or advanced cancer by combining large amounts of non-toxic chemicals. Research by 180 scientists from around the world has shown that non-toxic doses of plant and food products may solve the problem of cancer recurrence.
Professor Ferguson said, “Although we have achieved modest success in the treatment of certain cancers, the major problem left us is that most treatments, especially many new targeted therapies are extremely expensive, and they are extremely expensive. It has no effect on rare types of cancer and advanced cancer."
“Even if they seem to be working, a large percentage of patients will relapse in just a few months,†she said. “Usually advanced cancer is incurable, and cancer recurs when small mutant cell populations are resistant to treatment. Doctors try to solve this problem with combination therapy, but they find that the toxicity produced during treatment often prevents them from treating it. cancer."
[5] JPCB: Can red peppers also treat cancer?
Capsaicin is a burning compound in peppers that is commonly used in creams to help relieve pain. Recently, studies have shown that high doses of capsaicin can help kill prostate cancer cells; now published in the international journal The Journal In a research paper on Physical Chemistry B, researchers from abroad have discovered new clues that may help explain why capsaicin can kill prostate cancer cells, and related research may help researchers develop new therapies for prostate cancer. .
Scientists reported that about 10 years ago, capsaicin can help kill prostate cancer cells in the body of mice, but it is harmless to healthy cells. By converting to a dose suitable for humans, it may be necessary for individuals to take a large number of peppers every day. And revealing the working mechanism of capsaicin can help scientists develop new drugs for the treatment of prostate cancer in the form of injections or tablets.
[6] 2D Materials: Graphene-coated chemotherapy drugs can effectively treat cancer
Silver is commonly used as a coating on chemotherapeutic medical devices, but the problem is that silver coatings often destroy the efficacy of drugs. A recent research paper published in the international magazine 2D Materials, from the Norwegian University of Science and Technology in Trondheim Researchers have discovered that a graphene coating may help enhance the effects of chemotherapy.
Chemotherapy usually involves the patient taking an intravenous catheter for drug intake, and the devices on these catheters and their catheters are often coated with silver to help antibacterial, inhibit bacterial growth and unknown infections during therapy; The researchers analyzed the response of different drugs after contact with the silver coating. Silver can destroy the effects of chemotherapy drugs, the researcher Justin Wells said, we want to find the source of potential problems in the use of intravenous catheters, and the interaction of coatings and drugs is only a possibility, in general, chemotherapy drugs They are all active substances, so it is not difficult to imagine that the drug reacts with the silver coating.
[7] Ecancermedicalscience: antifungal drugs or can effectively treat cancer
Recently, in a research paper published in the international journal ecancermedicalscience, researchers from the ReDO (Tumor Research Program for Drug Reorientation) program have shown that a common antifungal therapy can be used to treat cancer. The ReDO program, a large-scale study of international anti-cancer scientists, is dedicated to the development of new drugs as a new type of cancer therapy.
The program has now published several research reports on drug development, and these drugs have some clinical evidence sufficient for clinical trials. Itraconazole is a drug used to treat a broad spectrum of fungal infections, including skin and nail infections. The drug may also be used as a new type of anticancer therapy. Pan Pantziarka noted that itraconazole has shown great potential in treating a range of cancer patients, especially non-small cell lung cancer and some rare malignancies.
[8] Appl Phy Lett: New magnetic material self-heating, high temperature treatment of cancer
Recently, researchers from Monash University in Australia have developed a special type of magnetic material that can achieve an extraordinary self-regulating heating effect, thus providing scientists with a new type of high-temperature cancer heat therapy. The ideas, related research published in the international magazine Applied Physics Letters.
Temperatures that can be "tolerated" by healthy cells of the body have been thought to destroy cancer cells, and a new method using magnetic particles may be introduced into tissues to achieve the goal of killing cancer cells for cancer treatment by heating, but this The new technology is far from being used as a standardized program. One of the problems that hinders the development of this heating technology is the insufficient heat capacity of the magnetic particles. In this study, the researchers discovered a new type of material that can not only be heated quickly, but also quickly block itself. The increase in heat.
[9] Oxygen treatment for cancer! New breakthrough in science medicine
A study by the New England Institute of Inflammation and Tissue Protection at Northeastern University and the University of Pittsburgh showed that more oxygen inhalation may promote immune cells to attack cancer. This inspiring study was published in the March 4 issue of Science Translational Medicine.
Tumors grow very rapidly and are faster than their blood supply. This causes a hypoxic environment that further stimulates cancer cells to produce adenosine and causes nearby T cells and natural killer cells to go into a dormant state. A large number of studies have attempted to block the adenosine effect and to develop drugs. The research team considered this issue from the perspective of oxygen supply.
The researchers asked mice with lung cancer to receive oxygen therapy (40-60% oxygen to treat the disease). They found that the added oxygen can change the tumor environment, so immune cells can enter the interior to exercise immunity. Moreover, the tumor shrinkage in the high oxygen group was more pronounced, especially when the researchers combined oxygen and injected additional anti-tumor T cells.
[10] reliable? Injecting bacteria can treat cancer?
Some ancient medical techniques may sometimes sound mad, but perhaps hidden secrets are worth using new techniques to continue research and exploration. Direct injection of toxic bacteria as a method of treating tumors does not seem to be very reliable, but a recent study by dogs and humans found that direct injection of bacteria into tumors can effectively control tumor growth and even completely eliminate tumors. On August 13, 2014, the research results were published online in Science Translational Medicine. It is easy to remind people of the study of malaria treatment of syphilis during World War I, which belongs to the concept of poisoning.
Clostridium oryzae is present in the soil and can cause infections in cattle, sheep and humans. Since the bacterium is an anaerobic bacterium and the tumor tissue happens to be an oxygen-deficient environment, the scientist deleted a toxin-producing gene of the bacterium, which is to transform the bacterium into a biological weapon that specifically attacks the tumor by reducing its toxicity. To infect and kill tumor cells, these bacteria are processed after the task is completed.
[11] The "potential stocks" for treating cancer may be in your medicine cabinet.
Where are the low-cost drugs for treating cancer? Does the common drug in the pharmacy represent the future development of cancer treatment? Re-use of drugs in oncology (ReDO) project organisms (this is an international collaboration between the Anti-Cancer Fund, Belgium and GlobalCures), and existing and widely used non-neoplastic drugs may be a new cancer-related drug The source of the drug for the treatment.
The focus of new drug development is currently targeted therapy for specific cancer pathways. Although the development of new drugs has made great progress, the side effects and low efficacy of this treatment are worrying; in addition, these high-cost new therapies make many patients out of reach. In contrast, there is strong evidence that some of the cheaper drugs commonly used to treat other diseases (such as diabetes, high blood pressure) have anti-cancer effects, and we can use combination therapy for anti-cancer treatment.
[12] Nature Series Review: Current Status and Prospects of Treating Cancer with Replication Stress
Recently, the Danish scientist Claus Storgaard S? Rensen published a review article in the international academic journals of nature reviews drug discovery, and summarized the research progress and prospects of cancer treatment using cancer cell DNA replication stress.
DNA replication in cancer cells is generally accompanied by prolonged and collapsed replication forks, as well as activation of signaling pathways that respond to DNA damage and immature mitosis, collectively referred to as "replication stress." There are many studies on replication stress processes that have made significant progress in this area, increasing the understanding of the molecular mechanisms regulating replication stress, and developing cancer treatment by enhancing replication stress. Means provide a lot of opportunities. In addition to delaying the progression of cancer cell cycle, cancer treatment can further promote cancer cells through cycle checkpoints, increase replication stress, and ultimately induce devastating failure of cell proliferation, thereby achieving the purpose of killing cancer cells for cancer treatment.
Source: Bio Valley
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