Release date: 2018-07-25
Three-dimensional model of the left ventricle of the human heart. Image Source: Physicist Organization Network
According to a report by the physicist organization network on the 23rd, researchers at Harvard University have developed a three-dimensional model of the left ventricle of human heart through bioengineering technology, which can be used for drug detection and disease therapy such as arrhythmia in the future.
The model uses nanofibers from human heart cells to form a scaffold to assist in the construction of tissue. This stent is like a three-dimensional template that guides cells and their tissues into the extrapulmonary ventricle. This allows scientists to further study cardiac function by using clinical tools such as pressure volume loops and ultrasound.
One of the main members of the research team, John Parker of Harvard University, John A. Paulson School of Engineering and Applied Science, Professor of Bioengineering and Applied Physics, said: "The entire team has spent more than a decade researching the project, the goal is to create a A complete heart. This progress is a very important step towards the ultimate goal."
Researchers say that once the model is put into use, it will have a huge and widespread impact in the field of cardiovascular disease regenerative medicine and in drug development as an in vitro model. The long-term goal of the project is to replace animal models with human models in medical research, or to compensate for the deficiencies of animal models. In the future, researchers can build tissue models by collecting patient stem cells to completely replicate their organ function and characteristics.
The key to creating a well-functioning ventricular model is to reshape the special architecture of the organization. In the human heart structure, the parallel arrangement of myocardial fibers acts as a scaffold, guiding the brick-like heart cells to end-to-end in a line-like arrangement, forming a hollow conical structure. When the heart beats, the heart cells stretch and contract like an accordion.
To create a ventricular model, the researchers placed the polymer of degradable polyester and gelatin fibers into a rotator in the shape of a bullet. As the instrument rotates, the fibers are lined up in the same direction, thus guiding the cells to move and contract like native cells.
The researchers said that the next step is to use patient-derived pre-differentiated stem cells for ventricular model research, which will help to form a more powerful organizational structure. (Intern Guo Zikai)
Source: Technology Daily
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