Research by Ning Guang and other Nature journals reveals the mechanism of benefit from Baixuping: related to intestinal flora
December 07, 2017 Source: China Circulation Magazine
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Academician Ningguang of Ruijin Hospital published a study in the Nature Journal, showing that the relationship between the efficacy of hypoglycemic agents and the characteristics of intestinal commensal flora has been established, not only for the first time, but also for the metabolic benefit of acarbose The mystery of the mechanism also provides new ideas for the design of new diabetes drugs that target the bile acid metabolism of intestinal symbiotic bacteria.
Studies have shown that acarbose can bring more metabolic benefits, such as weight loss, lipid lowering and improved insulin resistance, compared to glipizide.
Analysis of the intestinal flora before and after treatment showed that acarbose significantly changed the species composition of the intestinal flora and secondary bile acid metabolism.
After acarbose treatment, the abundance of various probiotics (such as bifidobacteria, lactic acid bacteria) was significantly increased, and the abundance of Clostridium and Bacteroides was greatly reduced. Measurement of the plasma concentrations of the patient's plasma and fecal bile acids confirmed that acarbose treatment can alter the bile acid metabolism profile.
Researchers believe that acarbose is likely to affect bile acid metabolism by altering the bile acid metabolism of intestinal microbes, thereby benefiting patients from various metabolic improvements other than hypoglycemic.
The study also found that the baseline intestinal commensal flora of patients with type 2 diabetes can be clearly divided into two types: B-type of Bacteroides-rich B and enterobacteria-rich P-type.
Compared with the P-type, B-type patients are more effective in receiving hypoglycemic drugs, including fasting blood glucose, insulin, C-peptide levels and insulin resistance, suggesting that intestinal symbiotic bacteria may be an important factor in determining the response of drugs. .
A total of 106 patients with type 2 diabetes who had not received medical therapy were randomized to the acarbose group and the glipizide group. After 3 months of treatment, both groups reached the target for glycemic control.
Reference: Gu Y, Wang X, Li J, Z et al. Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nat Commun. 2017 Nov 27;8(1):1785.
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