When we are attacked, we will counterattack, we will gather teams to attack the enemy, and we will continue to support and assist the injured comrades. This is a minimum attempt, but at the Gul Cancer Institute in the UK ( In the Cancer Research UK Gurdon Institute, this basic approach is probably not the most popular. Researcher Steve Jackson founded the institute 25 years ago, and now researchers have developed a new drug that can Use a counter-in-the-course approach to treating cancer by shutting down the mechanisms that repair the body's DNA and inhibiting DNA mutations.
Researcher Jackson, like other scientists in the Gurdon Institute, is a scientist engaged in basic research. In other words, his research is to clarify the basic mechanisms of the body's work, but basic science often lacks "fashion" but lacks basic research. We also cannot develop more new drugs for disease treatment. The drug, Lyparza, is based on research by Jackson, who received FDA approval in 2014 and has now been widely used in more than 40 countries.
In fact, the breakthrough moment of the researcher is the result of long-term observation, and Jackson also discovered an enzyme that can be activated by DNA, and this enzyme can actually be activated by DNA fragmentation, now in the laboratory. Most of the DNA used in the process is circular, but Jackson used long strips of DNA for related research. He said that if we use circular DNA for research, we may never see long strips of DNA. The effect of this special enzyme can be activated by DNA fragmentation, and the enzyme is also involved in the DNA repair process, which is the second DNA repair enzyme (PARP enzyme), which can help The development of the drug Olapani.
DNA repair is critical to our survival, and today we have evolved an alternate mechanism to prevent PAPR enzyme inactivation, a mechanism of homologous recombination, in which case DNA can be extended under the same fragment, In some cancer cells, it is worth mentioning that in the cancer cells with BRCA1 and BRCA2 mutations, the above mechanisms are often inactivated, and the tumor cells of the individual carrying these genes often carry two copies of the "bad" gene. It can promote the inactivation of the homologous recombination process, but the healthy cells of the body carry the correct genes, so that they can exercise the correct function.
The researchers point out that if we can block the PARP repair mechanism in these individual organisms, healthy cells may be able to restore function and survive, and tumor cells will die. One-third of patients with ovarian cancer are caused by mutations in the BRCA gene. Recent studies have shown that approximately the same proportion of patients with prostate cancer are directly related to BRCA mutations, and in one in ten breast cancer patients, If the drug Olapani can be approved, then the gas can improve the survival of many patients, but the drug is not perfect, it does not work for all BRCA patients and some drug-resistant patients, but can significantly prolong the patient Life expectancy.
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