It is caused by a virus. It is an acute infectious disease characterized by blistering inflammation of the oral mucosa with a large amount of runny nose. [pathogen] pathogen is infectious vesicular stomatitis virus, mainly in the diseased rabbit oral mucosal necrosis tissue and saliva, it was thought that the affected lymph nodes mink skin and leeches fluid also have a virus. The virus can be stored for 2 months in 50% glycerol, has strong resistance to low temperature, can survive for 3 days at 20 temperatures, but is sensitive to heat, and will soon die at 30°C and direct sunlight. The virus is insensitive to antibiotics and sulfonamides. Commonly used disinfectants are sodium hydroxide solution and peracetic acid solution. The disease is mainly associated with puppies less than 10 months of age. Ten weeks old young rabbits after weaning are the most common. Natural infection is mainly caused by the digestive tract. When feeding on feed or drinking water contaminated with pathogenic microorganisms, the virus can be transmitted through the oral mucosa. In addition, the bite of blood-sucking insects can also spread the disease. Mildew feed and barbed feed are often induced. The disease. [symptoms and lesions] The incubation period of this disease is 10 days. In the early stage of the disease, the oral mucosa was flushed and swollen. Miliose to lentil blister appeared on the mucous membranes of the lips, tongue and other parts of the oral cavity. After the blisters ruptured, plaques and ulcers formed. At the same time, a large number of drooling occurred, such as secondary bacterial infections. This results in necrosis of the lips, tongue, and oral mucous membranes, accompanied by foul odors. As a result of continuous depletion of large amounts of dehydration, mucus proteins and certain metabolites, systemic symptoms occur in young and young rabbits. Body temperature rises to 21, appetite diminishes or disappears, dyspepsia, diarrhea, progressive weight loss, death after 10 days, and mortality Up to 5%. At the time of the necropsy, the mucous membranes of the mouth, tongue, and lip were found to be blisters, erosions, and ulcers. The pharynx and larynx were covered with foamy saliva. The salivary glands were red and swollen. The stomach was dilated and filled with acidic mucus. The intestinal mucosa was catarrhal inflammation. [Diagnosis] According to the main clinical symptoms of salivation and oral inflammation, the combined age of onset is mostly at 1 month and a large number of young rabbits are found. There are no obvious lesions in the visceral organs after the death, and diagnosis can be made generally. If necessary, microbiological diagnosis can be performed. Susceptibility of oral lesions to susceptible rabbits is elicited with leeches and mink. [Prevention and Control] To create a good breeding and management condition, special attention should be paid to strengthening the sanitary and epidemic prevention measures in the Spring and Autumn Festival. Always check the forage quality to avoid excessively rough forage, burrs, sharp objects and other damage to the oral mucosa. Rabbits with rogue disease were found to be treated in isolation. At the same time, the house, rabbit cages, utensils, etc. were sterilized with sodium hydroxide solution or hot water. For suspected rabbits infected with sulfamethoxazole, 10 grams per kilogram body weight was taken once a day for drug prevention. There is no specific treatment for this disease. Local treatment: 1. Wash the oral cavity with antiseptic liquid (boric acid solution or alum solution, potassium permanganate solution, saline, etc.) and then apply iodoglycerin (1 part of iodine, 2 parts of glycerol) or sprinkle with yellow powder (or Ice boron scattered). Wash the oral cavity with copper sulfate solution, sprinkle with ice boron, 2 times a day, or use Qingdai San (10 grams of Qingyi, Huanglian, and Huangqi, 3 grams of catechu, borneol, and orange stalks, Mingjing grams, total research for the end Sprinkle the oral cavity, 3 grams each time, 5 times a day, take Viral Ling 1 tablet (20 grams), multivitamin 61 tablets twice a day, while taking sulfamethazine, sulfadiazine or antibiotics to control secondary infection. Feed with purple vitex, big green leaf, duckweed or a small amount of orange peel; or feed with honeysuckle, wild chrysanthemum, decoction and water.