Pemetrexed disodium
Alias: N-[4-[2- (2- amino -4,7- two hydrogen -4- oxo -1H- pyrrole [2,3-d] pyrimidine -5- base) ethyl] benzoyl]-L- glutamic acid two sodium
CAS 150399-23-8
English Name: Pemetrexed disodium
Molecular formula: C20H19N5NA2O6
Molecular weight: 471.37
[physicochemical properties]
Flash point: 160 C/20mm
Boiling point: 160 C 20mm
Melting point: 36-38 C
Character
This product is white to light yellow or green yellow freeze-dried solid.
pharmacological action
Pemetrexed enters the cells through folate carriers and the folate binding protein transport system on the cell membrane. Once pemetrexed enters the cell, it transforms into a form of glutamic acid under the action of the leaf glutamic acid synthetase. Polyglutamate is retained in cells as an inhibitor of thymidylate synthase and glycyamine nucleotidyl transferase. Glutamic acid showed a time - concentration dependent process in tumor cells, but the concentration in normal tissues was very low. The longer the half-life of multiple glutamic metabolites in tumor cells, the longer the time of action of drugs in tumor cells.
Preclinical studies showed that pemetrexed could inhibit the growth of mesothelioma cell lines (MSTO? 211H, NCI? H2052) in vitro. Mesothelioma cell line MSTO? 211H has shown synergistic effect of pemetrexed combined with cisplatin.
 API 99% CAS 150399-23-8 Pemetrexed disodium quality assuranceÂ
Pemetrexed disodium
Alias: N-[4-[2- (2- amino -4,7- two hydrogen -4- oxo -1H- pyrrole [2,3-d] pyrimidine -5- base) ethyl] benzoyl]-L- glutamic acid two sodium
CAS 150399-23-8
English Name: Pemetrexed disodium
Molecular formula: C20H19N5NA2O6
Molecular weight: 471.37
[physicochemical properties]
Flash point: 160 C/20mm
Boiling point: 160 C 20mm
Melting point: 36-38 C
Character
This product is white to light yellow or green yellow freeze-dried solid.
pharmacological action
Pemetrexed enters the cells through folate carriers and the folate binding protein transport system on the cell membrane. Once pemetrexed enters the cell, it transforms into a form of glutamic acid under the action of the leaf glutamic acid synthetase. Polyglutamate is retained in cells as an inhibitor of thymidylate synthase and glycyamine nucleotidyl transferase. Glutamic acid showed a time - concentration dependent process in tumor cells, but the concentration in normal tissues was very low. The longer the half-life of multiple glutamic metabolites in tumor cells, the longer the time of action of drugs in tumor cells.
Preclinical studies showed that pemetrexed could inhibit the growth of mesothelioma cell lines (MSTO? 211H, NCI? H2052) in vitro. Mesothelioma cell line MSTO? 211H has shown synergistic effect of pemetrexed combined with cisplatin.
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