The coating machine is an important tablet device in the pharmaceutical industry. During the long-term use of the coating machine, many problems often occur, such as electrical problems, mechanical problems, hot air system problems, and exhaust system problems. If these problems are not solved in time, they will affect the effect and quality of the coating to a certain extent, and even pollute the environment.
Before solving the problem, you need to understand the principle of the coating machine. When operating the coating machine, the plain film is usually placed in the drum of the coating machine, the drum is rotated clockwise, and then the syrup is added to the plain piece in the drum to make the sugar-coated piece roll in the drum. Rubbing, so that the sugar coating film is evenly wrapped. At the same time, hot air is introduced into the drum to quickly remove the moisture of the surface of the sugar coating film, and finally a uniform and smooth sugar-coated tablet is obtained. According to the process requirements, many links need to be controlled during the coating process, such as controlling the amount of air intake; controlling the rotational speed of the drum within a certain range; and controlling the heating of the drum and the intake air.
Through the operation process of the coating machine and the control system, the following shortcomings can be found. The control system of the coating machine mostly uses the relay to perform logic control in the form of machine wiring, and the control buttons are more, and the space occupied by the control cabinet is relatively large. . Moreover, due to the dust in the production environment, the button is likely to accumulate dust, which causes the equipment to malfunction, which is not convenient for the equipment to be cleaned, which may cause cleaning blind spots, affect the quality of the medicine, and cause equipment problems.
In this regard, there are coating machine manufacturers from the perspective of convenience, time saving, stability, etc., decided to carry out the following aspects of the transformation: the use of PLC instead of relays for system control; the use of touch screen as a human-machine interface operation instead of button operation; increase the analog input One module and one output module; the inverter is used to adjust the rotation speed of the drum. The frequency converter is a power control device that converts the power frequency power supply into another frequency by utilizing the on-off function of the power semiconductor device, which can realize soft start, frequency conversion speed regulation, improve operation precision, change power factor and overcurrent of the AC asynchronous motor. /Overvoltage / overload protection and other functions.
In addition, the manufacturer also starts from the system aspect, such as using the touch screen, controlling the start and stop of each actuator through the PLC and related modules; detecting and controlling the temperature through the FX2N-4AD-PT module of the PLC; RS-485 through the PLC The bus directly modifies the operating frequency of the inverter during operation.
But even so, there are many problems that have become apparent after long-term use. For example, mechanical problems, mechanical problems are relatively more, such as tug wear, the tug is the load-bearing parts of the drum, but also vulnerable items, the tug of different manufacturers are basically the same, the abnormal situation is basically caused by screw shedding and bearing necrosis The card wheel, the surface of the nylon wear caused by the drum beat.
There are also many common problems in the spray gun. For example, the clogging of the spray gun is a relatively common problem. The formation of the clogging is mainly caused by the problem of the design of the gas path of the spray gun. Some imported spray guns also have such design flaws. The dripping of the spray gun and the dripping of the spray gun basically occur when the gun is cleared. Many manufacturers say that the spray gun can be blocked by means of clearing the gun, but it is actually wrong. The blockage of the spray gun is divided into the hanging blockage and the membrane blockage. The clearing gun is the way of handling when the membrane is clogged.
Another example is the pulse of the spray gun. The pulse of the spray gun is mainly caused by the peristaltic pump. The pulse is a very important factor affecting the quality of the coating. There are many ways to eliminate the pulse, increase the length of the pipeline at the exit of the peristaltic pump, increase the adjustment structure and so on. Stirring unevenness is also a big problem. The coating liquid mixing tank is designed to be easy to clean. There is a large distance between the stirring blade on the stirring shaft and the bottom of the tank. If the distance is close, the stirring blade cannot be taken out for cleaning. Design flaws.
According to the combing and summary of the overall system problems of the coating machine, it is not difficult to find that the equipment still has defects in design and manufacture, and there are still many misunderstandings in the selection process. However, few manufacturers are now able to provide comprehensive equipment upgrades, replacements, and retrofit services, resulting in a significant increase in the cost of enterprise equipment and the constant emergence of problems. Therefore, the coating machine manufacturers also need to work hard on equipment design and manufacturing.
Hepatitis B Surface Antigen/AntibodyTest
INTENDED USE
Used for the qualitative detection of Hepatitis B surface
antigen in serum/plasma.
PRINCIPLE
The sample mixing up colloidal-gold monoclonal antibody move along the membrane to the T line, and form the T line when the human serum/plasma and whole blood contains HBsAg according to the principle of double antibody sandwich method and gold immunochromatography assay, which is a positive result. Unreacted markers move forward continuallyto combine with anti-mouse antibody and form a control line.
If the test line does not appear, it is a negative result.
MAIN COMPONENTS
Sample pad, colloidal gold marked pad, nitrocellulose membrane, absorbent paper and PVC board.
INTERPRETATION OF RESULTS
POSITIVE: Two distinct red lines appear. A red line in the
control region (C), and another red line in the test region (T). A pink to red line (T), even if it is very thin, indicates a positive
result.
NEGATIVE: A red line appears in the control region(C). No line
appears in the test region (T).
INVALID: No red lines appear or control line fails to appear.
Insufficient specimen volume or incorrect procedural
techniques are the most likely reasons. Review the procedure and repeat the test with a new test
device.
If the problem persists, discontinue using the kit and contact
your local distributor.
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Changchun ZYF science and technology CO.,LTD , https://www.zyf-medical.com