Motherwort is allowed to enter clinical trials
July 19, 2018 Source: Health News
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Under the continuous support of the national “Eleventh Five-Year Planâ€, “Twelfth Five-Year Plan†and “Thirteen Five-Year Plan†for the creation of major new drugs, Fudan University’s special lecture professor Zhu Yijun’s research team found that the monomer extracted and chemically synthesized from the Chinese herbal medicine Motherwort - Motherwort (also known as SCM-198) has significant effects on vascular protection and stroke treatment. It has been further studied by three high-lipid animal models, which have obvious lipid-lowering effects on hyperlipidemia.
It is reported that the results have been published in the latest issue of the international authoritative magazine "Pharmacology and Treatment", and recently obtained as a national major new drug creation and obtained the drug clinical trial approval issued by the State Drug Administration, and Phase I, II, III clinical The test was approved in one lump sum.
According to Zhu Yizhen, in order to obtain effective lipid-lowering compounds, the research team first carried out screening research from the Chinese medicines recorded in the Chinese Pharmacopoeia, and finally focused on the Chinese herbal medicines such as Motherwort, Salvia, Chuanxiong and Rhodiola. After numerous pharmacological demonstrations, it was finally discovered and confirmed that the traditional Chinese medicine motherwort has great research and development value.
Motherwort has the effect of improving blood circulation and promoting blood circulation, and is a traditional gynecological medication. However, for a long time, due to the high cost and high workload of extracting effective complexes in motherwort, the scientific value of the monomeric active ingredients has not been completely unearthed systematically. Later, Zhu Yiqi was inspired by the unique efficacy of Motherwort to improve blood circulation, and led the research team to use advanced technology to explore new synthetic routes and amplification processes. After more than five years of unremitting efforts, the research team finally succeeded in extracting the effective monomeric compound, motherwort, from the motherwort in 2007, and confirmed that it has obvious curative effect on treating stroke and lipid-lowering. Currently, the research has completed the motherwort. The pilot process is optimized and the purity has reached more than 99%, which provides a sufficient source of sustainable development for subsequent research.
To further confirm the lipid-lowering effect of leonurus, the research team began experimental research and first discovered that the unique lipid-lowering mechanism of motherwort is achieved through a new receptor (NOX-4), which is reduced by inflammation. fat. To accurately verify the lipid-lowering and anti-atherosclerotic activities of leonurus, they established three hyperlipidemia animal models, high-fat-fed gene knockout hyperlipidemia mice (one of the most important studies) An animal model of lipid efficacy), New Zealand hyperlipidemia white rabbits and hyperlipidemia rhesus monkeys attempt to provide new evidence for the development of new anti-atherosclerotic drugs. It was found that in lipid metabolism, 20 mg of motherwort per kilogram of knockout mice can effectively reduce total cholesterol, triglycerides and low-density lipoprotein in hyperlipidemia mice. In the New Zealand white rabbits, the lipid-lowering test also achieved promising results, given different doses of motherwort, can effectively reduce its triglycerides and total cholesterol. Taking 10 mg of motherwort per kilogram of hyperlipidemia rhesus monkey can effectively reduce serum total cholesterol. After 150 days of administration, the maximum lipid loss is 24.05%; after 178 days of administration, serum total cholesterol is decreased by 6.42%. Under the condition, the motherwort had a certain lowering effect on the low-density lipoprotein (a kind of bad cholesterol) in the serum, and the maximum decrease was 13.16% after 60 days of administration, and rebounded slightly after 178 days of administration. At the same time, at this dose, no significant increase in AST (aspartate aminotransferase) and ALT (alanine aminotransferase), which are highly toxic in animals, was found. The arterial vessels were normal and no significant changes were observed. This test also confirmed that the motherwort is non-toxic.
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