Release date: 2018-06-11
Although plasma proteins play an important role in biological processes and are direct targets for many drugs, so far we are not aware of the genetic factors that control individual differences in plasma protein levels in humans.
Image source: Wikimedia Commons
In order to reveal the individual differences in plasma proteins, scientists from institutions such as Cambridge conducted an in-depth analysis of the genes in the plasma of the healthy donors from the INTERVAL study under the leadership of Dr. John Danesh and Dr. Adam S. Butterworth. . They found 1927 genes associated with 1,478 proteins, five times the known number, and the related study was recently published in Nature, entitled "Genomic atlas of the human plasma proteome."
To explore the effects of disrupting plasma protein levels, the researchers used a comprehensive approach that links genetic mutations to biosignal pathways, disease and drug databases. Results The researchers found that the quantitative trait loci overlaps with gene expression loci and disease-associated loci. The researchers found a causal relationship between protein biomarkers and disease-causing by Mendelian random analysis.
By linking genes to diseases through special proteins, the researchers highlighted potential therapeutic targets that can guide existing drugs to work with new disease symptoms and help address the safety of the drug being developed.
Reference materials:
Benjamin B. Sun et al, Genomic atlas of the human plasma proteome, Nature (2018). DOI: 10.1038/s41586-018-0175-2
Source: Bio Valley
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