New gene therapy is expected to cure allergies

New gene therapy is expected to cure allergies

June 12, 2017 Source: Xinhua News Agency

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Australian scientists have invented a gene therapy that successfully cures asthma in experimental mice and is expected to be used once and for all to treat allergies, including asthma.

According to local media reports, the gene therapy developed by an immunology research team at the University of Queensland in Australia, by eliminating the "memory" of immune cells, prevents them from attacking related proteins and avoiding allergies.

The immune system protects the living organism from foreign pathogens, but sometimes mistakenly treats the harmless target as an "enemy" attack, triggering an allergic reaction. Allergic symptoms or severe asthma experienced by people are caused by the reaction of immune cells with proteins in allergens. Some severe allergic symptoms can significantly reduce the quality of life and may even kill you.

Ray Sputto, head of the research team, said that the difficulty in treating asthma and other allergies is that T cells in immune cells leave immune "memory" to allergen proteins and are therefore resistant to treatment.

In the experiment, the researchers extracted hematopoietic stem cells, transplanted a gene that regulates allergen proteins, and transplanted hematopoietic stem cells into experimental animals. These engineered stem cells differentiate and proliferate to form new blood cells that express this protein and target "close" immune cells to allergic reactions to the protein.

At present, the new therapy is only for asthma. The researchers hope to extend it to other allergic symptoms, including peanut allergy, seafood allergy, etc. The goal is to develop it into a simple and safe therapy to cure allergy symptoms at one time.

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