[ China Pharmaceutical Network Technology News ] How can we let bacteria learn the ability to produce drugs? Scientists usually use genetic engineering to solve this problem. If you can find the genes that correspond to the drug production, bring them into the body of the bacteria, and let them work, the bacteria can replace the original organism to produce drugs.
Nature is a treasure trove of drugs, and many drugs with good therapeutic effects come from natural ingredients produced by humans or other organisms. For example, penicillin is an antibiotic produced by the metabolism of Penicillium. Some of the drugs found in the laboratory are very effective, but they are often encountered in large-scale production: the chemical structure of natural substances is complex, and it is very troublesome to artificially synthesize, if the natural substances are originally found. For extraction, only a small amount can be obtained, which cannot meet the needs of large-scale use. At this time, small bacteria can solve this problem.
Bacteria have a strong ability to adapt to the environment, are not picky about the growing environment, and breed very quickly. Therefore, it is necessary to "raise" many bacteria to serve us at a relatively low cost. However, these bacteria themselves do not produce the drugs we need, how can we let them learn the ability to produce drugs?
Scientists often use genetic engineering to solve this problem. These drugs are usually proteins in the human body or other organisms, or are produced by enzymes that are synthesized under the corresponding gene "command". If you can find the genes that correspond to the drug production, bring them into the body of the bacteria, and let them work, the bacteria can replace the original organism to produce drugs.
In genetic engineering research, people first research organisms that produce natural medicines, and find genes that direct "drug synthesis" from their cells. Since then, scientists have used a method called polymerase chain reaction (PCR) to replicate many of the genes required for drug synthesis and ligated them to a plasmid (a small circular DNA molecule) that serves as a vector. One would first "cut" the plasmid with an enzyme that cleaves the DNA molecule, and then "paste" the gene fragment into it using ligase. Once such carriers are completed, they are introduced into the bacteria. Thus, the genes in the plasmid can be replicated in the bacteria and "direct" the bacteria to produce the drug.
Original title: Why genetic engineering can "direct" bacteria to produce drugs
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(Gene engineering can "direct" bacteria to produce drugs. Image Source: Baidu Pictures)
Nature is a treasure trove of drugs, and many drugs with good therapeutic effects come from natural ingredients produced by humans or other organisms. For example, penicillin is an antibiotic produced by the metabolism of Penicillium. Some of the drugs found in the laboratory are very effective, but they are often encountered in large-scale production: the chemical structure of natural substances is complex, and it is very troublesome to artificially synthesize, if the natural substances are originally found. For extraction, only a small amount can be obtained, which cannot meet the needs of large-scale use. At this time, small bacteria can solve this problem.
Bacteria have a strong ability to adapt to the environment, are not picky about the growing environment, and breed very quickly. Therefore, it is necessary to "raise" many bacteria to serve us at a relatively low cost. However, these bacteria themselves do not produce the drugs we need, how can we let them learn the ability to produce drugs?
Scientists often use genetic engineering to solve this problem. These drugs are usually proteins in the human body or other organisms, or are produced by enzymes that are synthesized under the corresponding gene "command". If you can find the genes that correspond to the drug production, bring them into the body of the bacteria, and let them work, the bacteria can replace the original organism to produce drugs.
In genetic engineering research, people first research organisms that produce natural medicines, and find genes that direct "drug synthesis" from their cells. Since then, scientists have used a method called polymerase chain reaction (PCR) to replicate many of the genes required for drug synthesis and ligated them to a plasmid (a small circular DNA molecule) that serves as a vector. One would first "cut" the plasmid with an enzyme that cleaves the DNA molecule, and then "paste" the gene fragment into it using ligase. Once such carriers are completed, they are introduced into the bacteria. Thus, the genes in the plasmid can be replicated in the bacteria and "direct" the bacteria to produce the drug.
Original title: Why genetic engineering can "direct" bacteria to produce drugs
Teach you to use APP (Pharmaceutical Pass) to seize business opportunities
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