The School of Optoelectronics of Shenzhen University recently announced that the team of academicians of the school, together with Tsinghua University, Zheyuan Technology, the University of Hong Kong, Lemon Data, and the University of Texas at Dallas, have independently built 3D random optical reconstruction microscopes (3D). On the -STORM) platform, a diagnostic optical imaging-based diagnostic tool was developed to obtain 3D super-resolution images of DNA sequences of only 2,500 bases in the context of a complex nuclear environment. This is an image of the shortest specific DNA sequence observed so far in the nucleus, and the related work was recently published in the international high-level open journal eLife.
Professor Zhang Qiwei, a co-author of Tsinghua University and the University of Texas at Dallas, said that the traditional FISH method is limited by various factors (including labeling ability and optical resolution) and it is difficult to obtain clear microscopic images of specific short fragments in the genome.
“Although this technique is promising in the study of the fine organization of chromatin domains, we hope to develop a new method: not only to further improve the resolution of the genome sequence, but also to avoid the cumbersome probe preparation process to the actual The limitations of the application, Professor Zhang Qiwei said, this new method can accurately target gene enhancers and promoters, interact, visualize in situ, and can be used to detect specific DNA in single cells in cancer and other diseases. Small fragments and changes in their interactions.
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