Release date: 2014-08-06
Beijing time on August 5th news, Science Daily reported that researchers at the University of California, San Diego, reported that the diet capsaicin, an active ingredient in peppers, causes chronic activation of intestinal cell cortical receptors in mice, triggering a The response, which reduces the risk of colorectal tumors. The discovery was published in the August 1 issue of the journal Clinical Research.
The receptor or ion channel called TRPV1 was first discovered in sensory neurons, and it acts as a guard against the heat, acid and spicy chemicals in the environment. “It’s all potentially harmful stimuli to cells,†says research author Eyal Raz, a medical professor. "Therefore, TRPV1 is described as a molecular 'pain sensor'." This can be thought of as its traditional function, all in the nervous system.
However, Russ and colleagues found that intestinal epithelial cells also express TPRV1, which is primarily activated by the epidermal growth factor receptor or EGFR. EGFR is a driving force for intestinal cell proliferation, and the epithelial layer is replaced by replacement every 4 to 6 days. "In order to maintain the renewal of normal cells in the internal organs, the basic level of EGFR activity must be guaranteed," said the first author, University of California, San Diego, and the University of Utrecht Medical Center in the Netherlands, Petrus de Jong. ) Said this. “However, if the EFGR signal is unlimited, then the risk of fragmented tumor development increases.â€
Scientists have found that once TRPV1 is activated by EFGR, it initiates direct negative feedback to EFGR, inhibiting the latter to reduce unwanted growth and the risk of intestinal tumor development. They found that mice with insufficient TRPV1 were exposed to a higher than average intestinal tumor growth rate after genetic modification.
"These results show that epithelial TRPV1 generally acts as an intestinal tumor suppressor," De Rong said. In addition, molecular studies of human colorectal cancer samples have recently revealed multiple variants of the TRPV1 gene, although Russ said there is no direct evidence that TRPV1 deficiency is a risk factor for colorectal cancer in humans. "Future clinical studies should investigate the direct correlation between TRPV1 function and human colorectal cancer."
If this is the case, current research suggests that a potential remedy is capsaicin, a mammalian irritant that produces a burning sensation in contact with tissue. Capsaicin has been widely used as an analgesic for topical ointments, and its characteristics as irritants have surpassed the nerves, which makes it impossible for nerves to report pain in time. Capsaicin is also a major component of pepper spray.
The researchers fed capsaicin to genetically modified mice that developed multiple tumors in the gastrointestinal tract. This treatment resulted in a reduction in tumor burden and a 30% increase in life expectancy in mice. This treatment is even more effective when combined with Celecoxib, a selective COX-2 non-steroidal anti-inflammatory drug. Celecoxib has been approved for the treatment of certain forms of arthritis and pain. "Our data suggest that individuals with a risk of developing a recurrent intestinal tumor may benefit from chronic TRPV1 activation," Russ said. "We have provided proof of the principle."
Other co-authors of the study included Naoki Takahashi of the University of California, San Diego School of Medicine and the School of Medicine and Dental Medicine, Niigata University, and Alexandra R., of the University of California, San Diego School of Medicine. Harris), Jihyung Lee, Samuel Bertin, James Jeffries, Michael Jung, Jen Duong, Ai Amy I. Triano, Jongdae Lee, David S. Herdman, Hui Dong, Lars Eckmann And Maripat Corr; Yaron Niv of the Rabin Medical Center at Tel Aviv University, Israel; University of California San Diego School of Medicine and Koji Taniguchi of the Keio University School of Medicine, Japan );Chang-Whan Kim of the University of California San Diego School of Medicine and the Catholic University of Korea, and Stephanie M Stanford and Nuzio of the Laguila Institute of Allergy and Immunity, California, USA Nunzio Bottini.
Source: Phoenix Technology
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