The so-called
pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. This kind of chemical product can be produced in an ordinary chemical factory without the production license of the medicine. As long as it reaches some level, it can be used for the synthesis of medicines.
After nearly 30 years of development, China's pharmaceutical intermediates industry has grown from a small branch of the chemical industry to an emerging industry with a production value of several billion yuan, and its competition has also become more competitive. In the early stage of the development of the industry, due to the small investment and high rate of return, pharmaceutical intermediate companies have sprung up, especially in Zhejiang Huangyan, Taizhou, Nanjing Jintan, Shijiazhuang, Jinan, Northeast and other areas with favorable conditions for the development of pharmaceutical intermediates. Development is particularly rapid.
At present, the production of new drugs on the market is limited, which makes the development of new products in the pharmaceutical intermediate industry more and more difficult, the competition of traditional products is becoming more and more fierce, and the profits of the pharmaceutical intermediate industry are rapidly declining.
1. Improve technology and save cost The pharmaceutical intermediates have long process routes, many reaction steps, large solvent usage, and great potential for technological improvement. For example, a lower value raw material can be used instead of a higher value raw material, such as replacing liquid bromine in the production of ammonia thiocyanate, using ammonium thiocyanate in place of potassium thiocyanate (sodium) in production, and using a single solvent instead of the reaction. The different solvents, the alcohol produced by hydrolysis of the ester product is recovered.
2, the formation of their own unique products in the industry has greater influence.
3. Upward and downstream extension of the industrial chain to extend the main raw materials used by itself to self-production, which can further reduce costs, and at the same time, for some special raw materials, can play a role in avoiding the monopoly of key raw materials. The downward extension of the pharmaceutical intermediate directly synthesizes the bulk drug, which can further increase the added value of the product and directly sell the product to the pharmaceutical company. However, the investment in the downstream is relatively large, and at the same time, the production technology is highly demanded, and it is necessary to maintain a good relationship with the manufacturers of the raw materials.
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