Recently, a study by scientists from institutions such as the University of Amsterdam in the Netherlands found that a "electric shock" device capable of producing bioelectricity has a significant improvement in the arthritis of patients.
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Experimental therapy schematic
In a clinical trial, scientists surgically implanted bioelectric devices into the vicinity of the vagus nerve in 17 patients with rheumatoid arthritis, and in the next 84 days, vagus nerve stimulation was given at device timing. The results showed that the symptoms of these patients showed significant relief according to the internationally accepted arthritis activity index DAS28-CRP. It is worth noting that several of these patients have received multiple drug treatments, but none of them have any significant effect. In addition, subjects did not show adverse side effects during the trial. Further studies have shown that this electrical stimulation can significantly reduce the production of tumor necrosis factor (TNF) in the lesions of patients, thereby alleviating the symptoms of rheumatoid arthritis. This result was published in the latest issue of PNAS.
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Inflammatory reflex arc
The researchers believe that this is due to the above-mentioned bioelectric device stimulation of the inflammatory reflex. The inflammatory reflex arc refers to a neural reflex pathway: when the nerve endings sense a molecular signal change in the inflammatory region caused by infection or injury, the information is transmitted to the nerve center via the afferent nerve, and then the efferent nerve The neurotransmitter is released, which acts on immune inflammatory cells to regulate the inflammatory response. Recent studies have shown that acetylcholine released by the vagus nerve is a neurotransmitter that binds to the α7 nicotinic acetylcholine receptor (α7 nAChR) expressed on inflammatory immune cells (monocytes, neutrophils, etc.). Further, a cholinergic anti-inflammatory pathway is formed.
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