Release date: 2015-05-18
Recently, researchers from the Georgia Institute of Technology and King's College found that information on food-rich neuronal, food-rich information is encoded by the gene levels of serotonin and the TGF-beta pathway. The signals of these nervous systems can affect the lifespan of animals and thus mediate the effects of food on aging. The discovery was recently published in eLife magazine.
Diet has a very important impact on health and aging. The nervous system plays an important role in this process. However, how the nervous system decodes the food signal is still a mystery. This is an important issue because the decoding of food signals by the nervous system affects not only aging, but also health and disease, including metabolism, regeneration and development.
Using researchers as nematodes, the researchers found that serotonin and the TGF-beta pathway play an important role in linking food richness to the nervous system. Mutual regulation and autoregulation between these two pathways altered the shape, dynamic range and population variance of DAF-7 (TGF-beta) and TPH-1 (tryptophan hydroxylase) gene expression responses to food supplies. These complex regulatory properties provide a different mechanism for TGF-beta and serotonin signaling to coordinate the accuracy of this multi-neuronal code: daf-7 primarily regulates gene expression diversity, while TPH-1 primarily regulates gene expression. The dynamic range of the reaction. When the researchers mutated daf-7 and tph-1, they could reduce life-threatening dependence on food supply.
The serotonin and TGF-beta pathways play a role in a variety of human diseases, including cancer, mental illness, diabetes and obesity. Because many important genes, nematodes and humans, play a similar role, the science has discovered many genetic pathways related to human physiology and disease using the simple multicellular model of nematodes.
This research is to use the biological model of nematodes to reveal the neural code that perceives the richness of things, that is, the level of gene expression can be used as information processing for nervous system regulation.
Source: Bio Valley
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